Jedrziewski M Kathryn, Lee Virginia M-Y, Trojanowski John Q
The Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Alzheimers Dement. 2007 Apr;3(2):98-108. doi: 10.1016/j.jalz.2007.01.009.
The industrialized nations are experiencing a demographic revolution due to the continuing increase in longevity and the rapid rise in the percentage of the population over 65 years old. Interventions that promote healthy aging will continue to gain significance as efforts to delay disability and loss of function intensify.
Since physical activity has been implicated in promoting healthy aging, here we review a large body of research that examines physical activity and cognitive health. Specifically, we focus on the associations of physical activity with cognitive function and dementia, including prevention, delay or slowing down of disease progression. Thus, we have prepared a descriptive review of the literature including various types of publications, prospective cohort, case-control, clinical trial and meta-analysis papers, published since 1999 in peer-reviewed journals.
Based on currently available data, we conclude that the relative risk of cognitive decline with aging may diminish in individuals who are physically active; however, this has not been definitively demonstrated thus far.
Further research is needed to determine conclusively the effects of physical activity on cognitive function and dementia and to elucidate the basis for this linkage.
由于寿命持续延长以及65岁以上人口比例迅速上升,工业化国家正在经历一场人口结构变革。随着延缓残疾和功能丧失的努力不断加强,促进健康老龄化的干预措施将继续变得重要。
由于体育活动与促进健康老龄化有关,在此我们综述了大量研究体育活动与认知健康的研究。具体而言,我们关注体育活动与认知功能和痴呆症的关联,包括疾病预防、延缓或减缓疾病进展。因此,我们对1999年以来在同行评审期刊上发表的各种类型的出版物、前瞻性队列研究、病例对照研究、临床试验和荟萃分析论文进行了文献描述性综述。
根据目前可得的数据,我们得出结论,身体活跃的个体随着年龄增长出现认知衰退的相对风险可能会降低;然而,到目前为止这一点尚未得到确凿证明。
需要进一步研究以最终确定体育活动对认知功能和痴呆症的影响,并阐明这种联系的基础。