Gerardi Gabriele, De Ninno Antonella, Prosdocimi Marco, Ferrari Vanni, Barbaro Filippo, Mazzariol Sandro, Bernardini Daniele, Talpo Getullio
1Department of Veterinary Clinical Sciences, University of Padua, Agripolis, Viale dell'Università 16, 35020 Legnaro, Padua, Italy.
Biomagn Res Technol. 2008 Apr 1;6:3. doi: 10.1186/1477-044X-6-3.
A series of experiments on rats have been performed, to study the effects of long time (50 days) exposure to electromagnetic fields of extremely low frequency (ELF, i.e. less than 100 Hz) and amplitude (non thermal), testing whether the metabolic processes would be affected. The background lies on recent observations on the behaviour of isolated enzymes in vitro exposed to EFL fields. In these experiments, the cyclotron (or Larmor) frequency of the metallic ion has been used to "stimulate" the metalloproteins redox-active site, thus obtaining a clear variation of the enzyme functionality. In this paper we have extended for the first time the check to more complex animal metabolism. The novelty of this approach implies that a large amount of data had to be analyzed since it was not possible, in principle, to select only a few parameters among all the potential effects. Several biochemical parameters have been evaluated by comparing their values during the periods of exposure (field ON) and non exposure (field OFF). The evidence that long term exposure to electromagnetic fields with a well defined frequency may have relevant effects on parameters such as body weight, blood glucose and fatty acid metabolism has been obtained.
已经对大鼠进行了一系列实验,以研究长时间(50天)暴露于极低频(ELF,即低于100Hz)和振幅(非热)的电磁场的影响,测试代谢过程是否会受到影响。背景基于最近对体外暴露于极低频电磁场的分离酶行为的观察。在这些实验中,金属离子的回旋加速器(或拉莫尔)频率已被用于“刺激”金属蛋白的氧化还原活性位点,从而使酶的功能发生明显变化。在本文中,我们首次将检查扩展到更复杂的动物代谢。这种方法的新颖性意味着必须分析大量数据,因为原则上不可能在所有潜在影响中仅选择几个参数。通过比较暴露期(磁场开启)和非暴露期(磁场关闭)期间的数值,评估了几个生化参数。已经获得证据表明,长期暴露于具有明确频率的电磁场可能会对体重、血糖和脂肪酸代谢等参数产生相关影响。