Torres-Duran Patricia V, Ferreira-Hermosillo Aldo, Juarez-Oropeza Marco A, Elias-Viñas David, Verdugo-Diaz Leticia
Department of Physiology, School of Medicine, UNAM, P.O. Box 70250, Mexico, D.F. 04510, Mexico.
Lipids Health Dis. 2007 Nov 16;6:31. doi: 10.1186/1476-511X-6-31.
[corrected] The effects of extremely low-frequency electromagnetic fields (ELF-EMF) on the blood serum and liver lipid concentrations of male Wistar rats were assessed.
Animals were exposed to a single stimulation (2 h) of ELF-EMF (60 Hz, 2.4 mT) or sham-stimulated and thereafter sacrificed at different times (24, 48 or 96 h after beginning the exposure).
Blood lipids showed, at 48 h stimulated animals, a significant increase of cholesterol associated to high density lipoproteins (HDL-C) than those observed at any other studied time. Free fatty acid serum presented at 24 h significant increases in comparison with control group. The other serum lipids, triacylglycerols and total cholesterol did not show differences between groups, at any time evaluated. No statistical differences were shown on total lipids of the liver but total cholesterol was elevated at 24 h with a significant decrease at 96 h (p = 0.026). The ELF-EMF stimulation increased the liver content of lipoperoxides at 24 h.
Single exposures to ELF-EMF increases the serum values of HDL-C, the liver content of lipoperoxides and decreases total cholesterol of the liver. The mechanisms for the effects of ELF-EMF on lipid metabolism are not well understand yet, but could be associated to the nitric oxide synthase EMF-stimulation.
[已修正]评估了极低频电磁场（ELF-EMF）对雄性Wistar大鼠血清和肝脏脂质浓度的影响。
将动物暴露于ELF-EMF（60Hz，2.4mT）单次刺激（2小时）或假刺激，然后在不同时间（开始暴露后24、48或96小时）处死。
在刺激48小时的动物中，血脂显示与高密度脂蛋白相关的胆固醇（HDL-C）显著高于其他任何研究时间。与对照组相比，游离脂肪酸血清在24小时时显著增加。在任何评估时间，其他血清脂质、三酰甘油和总胆固醇在各组之间均未显示差异。肝脏总脂质无统计学差异，但总胆固醇在24小时时升高，在96小时时显著降低（p = 0.026）。ELF-EMF刺激在24小时时增加了肝脏中脂质过氧化物的含量。
单次暴露于ELF-EMF会增加HDL-C的血清值、肝脏中脂质过氧化物的含量，并降低肝脏总胆固醇。ELF-EMF对脂质代谢影响的机制尚不完全清楚，但可能与一氧化氮合酶的EMF刺激有关。
