Yasumura S, Shimizu Y, Yasuyama T, Hiroki O, Okada K, Tsukishiro T, Tsuchida T, Higuchi K, Watanabe A
Third Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Acta Med Okayama. 1991 Dec;45(6):457-9. doi: 10.18926/AMO/32181.
Immune responses to hepatitis B virus (HBV) vaccine in six low- or non-responded health-care workers were tested with an intradermal low dose (5 micrograms) of the recombinant vaccine. The injection was repeated three or four times at fortnightly intervals. These successive doses of the vaccine induced a high concentration of antibodies with delayed-type hypersensitivity (DTH) skin reactions in all six subjects. A few minor temporary side effects, such as irritation and itching at the injection site, were reported by some of the vaccinees. The results suggest low-dose of intradermal HBV vaccinations for low- or non-responders are safe and readily effective.
对6名低应答或无应答的医护人员，采用皮内低剂量（5微克）重组乙肝病毒（HBV）疫苗进行免疫反应测试。每隔两周重复注射3次或4次。这些连续剂量的疫苗在所有6名受试者中均诱导产生了高浓度抗体，并伴有迟发型超敏反应（DTH）皮肤反应。部分接种者报告了一些轻微的暂时副作用，如注射部位的刺激和瘙痒。结果表明，低剂量皮内接种HBV疫苗对低应答者或无应答者是安全且有效的。
