Wiström J, Gustafsson A
Department of Infectious Diseases, University Hospital Umeå, Sweden.
Scand J Infect Dis. 1990;22(5):621-2. doi: 10.3109/00365549009027107.
Intradermal vaccination with recombinant hepatitis B vaccine was performed in 33 children (mean age 3.3 years). A 2 micrograms dose was given at 0, 1 and 6 months and antibody responses were determined 20 months after the initial dose. In 32/33 children, serum antibodies to HBs were demonstrated, with a geometric mean level of 26.5 IU/l, and 24 children (73%) had anti-HBs levels greater than or equal to 10 IU/l. The results indicate that intradermal vaccination with recombinant hepatitis B vaccine may be an alternative for vaccination of small children.
对33名儿童（平均年龄3.3岁）进行了重组乙肝疫苗皮内接种。在0、1和6个月时给予2微克剂量，并在首次给药后20个月测定抗体反应。在33名儿童中的32名中检测到了抗-HBs血清抗体，几何平均水平为26.5 IU/l，24名儿童（73%）的抗-HBs水平大于或等于10 IU/l。结果表明，重组乙肝疫苗皮内接种可能是幼儿接种疫苗的一种替代方法。
