Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Capio Spine Center Stockholm, Löwenströmska Hospital, Box 2074, 194 02, Upplands-Vasby, Stockholm, Sweden.
Eur Spine J. 2024 Aug;33(8):3099-3108. doi: 10.1007/s00586-024-08312-8. Epub 2024 May 21.
We aimed to investigate surgical outcomes in octogenarians with subaxial cervical spine injuries and determine the predictors of complications and mortality.
Eligible for inclusion were all patients surgically treated between 2006 and 2018, with either anterior or posterior fixation for subaxial spine injuries. A cohort of octogenarians was identified and matched 1:1 to a corresponding cohort of younger adults. Primary outcomes were perioperative complications and mortality.
Fifty-four patients were included in each of the octogenarian and younger groups (median age: 84.0 vs. 38.5). While the risks for surgical complications, including dural tears and wound infections, were similar between groups, the risks of postoperative medical complications, including respiratory or urinary tract infections, were significantly higher among the elderly (p < 0.05). Additionally, there were no differences in operative time (p = 0.625) or estimated blood loss (p = 0.403) between groups. The 30 and 90-day mortality rates were significantly higher among the elderly (p = 0.004 and p < 0.001). These differences were due to comorbidities in the octogenarian cohort as they were revoked when propensity score matching was performed to account for the differences in American Society of Anesthesiology (ASA) grade. Multivariable logistic regression revealed age and ASA score to be independent predictors of complications and the 90-day mortality, respectively.
Octogenarians with comorbidities were more susceptible to postoperative complications, explaining the increased short-term mortality in this group. However, octogenarians without comorbidities had similar outcomes compared to the younger patients, indicating that overall health, including comorbidities, rather than chronological age should be considered in surgical decision-making.
本研究旨在探讨 80 岁以上下颈椎损伤患者的手术治疗效果,并确定并发症和死亡率的预测因素。
本研究纳入了 2006 年至 2018 年间接受前路或后路固定治疗的下颈椎损伤患者。将 80 岁以上的患者确定为一个队列,并与相应的年轻患者进行 1:1 匹配。主要结局是围手术期并发症和死亡率。
80 岁以上组和年轻组各纳入 54 例患者(中位年龄:84.0 岁 vs. 38.5 岁)。虽然两组手术并发症(包括硬脊膜撕裂和伤口感染)的风险相似,但老年组术后内科并发症(包括呼吸道或尿路感染)的风险显著更高(p<0.05)。此外,两组的手术时间(p=0.625)或估计失血量(p=0.403)无差异。老年组的 30 天和 90 天死亡率显著更高(p=0.004 和 p<0.001)。这些差异是由于 80 岁以上患者组存在合并症所致,但在进行倾向评分匹配以考虑美国麻醉医师协会(ASA)分级差异后,这些差异被消除。多变量逻辑回归显示,年龄和 ASA 评分是并发症和 90 天死亡率的独立预测因素。
患有合并症的 80 岁以上患者更容易发生术后并发症,这解释了该组患者短期死亡率增加的原因。然而,无合并症的 80 岁以上患者与年轻患者的结局相似,这表明在手术决策中应考虑整体健康状况(包括合并症),而不是单纯考虑年龄。