Intiso Domenico, Basciani Mario, Di Rienzo Filomena, Tolfa Maurizio, Grimaldi Giuseppina, Fiore Piero
Department of Neuro-Rehabilitation, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy.
J Rehabil Med. 2008 Apr;40(4):315-6. doi: 10.2340/16501977-0190.
Use of botulinum toxin is expanding as clinical studies demonstrate new potential therapeutic applications. In rehabilitation, botulinum toxin is predominantly used as adjunct therapy for the treatment of spasticity, but it may prove useful for other atypical clinical situations.
A 73-year-old man had a severe sub-arachnoid haemorrhage following the rupture of a giant aneurism of the middle left cerebral artery. Clinically, the patient presented a vegetative state and an oro-mandibular dyskinesia that produced a chronic ulcer on the lower lip. As treatment for this dyskinesia, a total of 320 U botulinum toxin type A were injected into the upper and lower orbicularis oris and masseter muscles.
This treatment allowed for application of topical medication and subsequently, ulcer healing. Botulinum toxin type A may be an important therapeutic aid for clinicians faced with treating persistent pathological conditions caused by dyskinesia.
随着临床研究证明肉毒杆菌毒素有新的潜在治疗应用，其使用范围正在扩大。在康复治疗中，肉毒杆菌毒素主要用作治疗痉挛的辅助疗法，但它可能对其他非典型临床情况也有用。
一名73岁男性因左大脑中动脉巨大动脉瘤破裂发生严重蛛网膜下腔出血。临床上，该患者呈植物人状态，伴有口下颌运动障碍，下唇出现慢性溃疡。作为对这种运动障碍的治疗，共向口轮匝肌上下部和咬肌注射了320单位A型肉毒杆菌毒素。
这种治疗使得能够应用局部用药，随后溃疡愈合。A型肉毒杆菌毒素对于面临治疗由运动障碍引起的持续性病理状况的临床医生而言可能是一种重要的治疗辅助手段。
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