A型肉毒杆菌毒素对一名植物人状态患者口下颌运动障碍后溃疡愈合的作用

Botulinum toxin type A in the healing of ulcer following oro-mandibular dyskinesia in a patient in a vegetative state.

作者信息

Intiso Domenico, Basciani Mario, Di Rienzo Filomena, Tolfa Maurizio, Grimaldi Giuseppina, Fiore Piero

机构信息

Department of Neuro-Rehabilitation, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy.

出版信息

J Rehabil Med. 2008 Apr;40(4):315-6. doi: 10.2340/16501977-0190.

DOI:10.2340/16501977-0190

PMID:18382829

Abstract

OBJECTIVE

Use of botulinum toxin is expanding as clinical studies demonstrate new potential therapeutic applications. In rehabilitation, botulinum toxin is predominantly used as adjunct therapy for the treatment of spasticity, but it may prove useful for other atypical clinical situations.

CASE HISTORY

A 73-year-old man had a severe sub-arachnoid haemorrhage following the rupture of a giant aneurism of the middle left cerebral artery. Clinically, the patient presented a vegetative state and an oro-mandibular dyskinesia that produced a chronic ulcer on the lower lip. As treatment for this dyskinesia, a total of 320 U botulinum toxin type A were injected into the upper and lower orbicularis oris and masseter muscles.

RESULTS AND DISCUSSION

This treatment allowed for application of topical medication and subsequently, ulcer healing. Botulinum toxin type A may be an important therapeutic aid for clinicians faced with treating persistent pathological conditions caused by dyskinesia.

摘要