Rao Lakshmana B, Sangur Rajashekar, Pradeep S
Department of Prosthodontics, Rama Dental College, Kanpur, India.
Indian J Dent Res. 2011 May-Jun;22(3):440-5. doi: 10.4103/0970-9290.87068.
An extremely effective way of preventing damage to and enhancing treatment of dental hard tissues and restorations would be to ''de-programme'' the muscles responsible for excessive destructive forces and other gnathological-related diseases. The new paradigm is the intramuscular injection of Botulinum toxin type A (BOTOX) into the affected muscles. It is a natural protein produced by anaerobic bacterium, Clostridium botulinum. The toxin inhibits the release of acetylcholine (ACH), a neurotransmitter responsible for the activation of muscle contraction and glandular secretion, and its administration results in reduction of tone in the injected muscle. There are seven distinct serotypes of Botulinum toxin, viz., A, B, C, D, E, F, and G, which differ in their potency, duration of action, and cellular target sites. This paper describes the different applications of BOTOX in dentistry.
预防牙硬组织损伤并加强其治疗的一种极其有效的方法是，使造成过度破坏力及其他与颌学相关疾病的肌肉“去程序化”。新的治疗模式是向受影响的肌肉内注射A型肉毒杆菌毒素（保妥适）。它是由厌氧细菌肉毒杆菌产生的一种天然蛋白质。该毒素会抑制乙酰胆碱（ACH）的释放，乙酰胆碱是一种负责激活肌肉收缩和腺体分泌的神经递质，注射该毒素会使被注射肌肉的张力降低。肉毒杆菌毒素有七种不同的血清型，即A、B、C、D、E、F和G，它们在效力、作用持续时间和细胞靶点方面存在差异。本文介绍了保妥适在牙科的不同应用。
