Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Toxins (Basel). 2022 Jun 14;14(6):406. doi: 10.3390/toxins14060406.
The normal biological wound healing process consists of three precisely and highly programmed phases that require optimal conditions including internal and external factors. Any negative factors that disrupt the sequence or time frame of the healing mechanism can result in a non-healing wound or chronic ulcers. Botulinum neurotoxin A (BoNT-A) which is generally known as anti-contraction of muscles has been reported as a successful treatment in various types of chronic ulcers. The aim of this study is to review the outcome of treatment with BoNT-A for chronic skin ulcers. The results demonstrated some positive effects of BoNT-A on chronic ulcers. Ischemic ulcers secondary to Raynaud's phenomenon seem to be the most promising type of ulcers that have benefited from BoNT-A. The rationale behind using BoNT-A to fasten the wound healing process is also discussed. Further clinical trial studies should be conducted to affirm the efficacy of wound healing using BoNT-A administration.
正常的生物伤口愈合过程由三个精确且高度程序化的阶段组成，需要包括内部和外部因素在内的最佳条件。任何破坏愈合机制顺序或时间框架的负面因素都可能导致不愈合的伤口或慢性溃疡。肉毒杆菌神经毒素 A（BoNT-A）通常被认为是肌肉的抗收缩作用，已被报道可成功治疗各种类型的慢性溃疡。本研究旨在综述 BoNT-A 治疗慢性皮肤溃疡的疗效。结果表明，BoNT-A 对慢性溃疡有一些积极影响。继发于雷诺现象的缺血性溃疡似乎是最有希望受益于 BoNT-A 的溃疡类型。使用 BoNT-A 加速伤口愈合过程的基本原理也进行了讨论。应进行进一步的临床试验研究，以证实使用 BoNT-A 给药促进伤口愈合的疗效。
