Hu Wensheng, Wang Zhengping, Wang Hanzhi, Huang Hefeng, Dong Minyue
Women's Hospital, School of Medicine, Zhejiang University, Zhejiang Province, China.
Acta Obstet Gynecol Scand. 2008;87(4):413-8. doi: 10.1080/00016340801976012.
To characterise the changes in serum visfatin levels in late normal pregnancy and pre-eclampsia.
Twenty-seven women with pre-eclampsia were recruited. Twenty-eight women in the third trimester of normal pregnancy served as pregnant control and 28 healthy non-pregnant women as non-pregnant control. Serum levels of visfatin were measured with an enzyme-linked immunosorbent assay.
The means of serum visfatin were 626.4+/-45.5 ng/ml (mean+/-SEM) in non-pregnant control, 695.9+/-92.5 ng/ml in pregnant control, and 308.3+/-80.0 ng/ml in pre-eclampsia, respectively, and were significantly different among the groups (p<0.001). Visfatin level was significantly lower in pre-eclampsia compared to non-pregnant control (p=0.004) and pregnant control (p<0.001). Women with severe pre-eclampsia had a significantly lower serum visfatin level than those with mild pre-eclampsia (114.6+/-80.9 versus 425.2+/-122.1 ng/ml, p=0.037).
A decrease in visfatin level was demonstrated in pre-eclampsia, suggesting that visfatin and adipokine-associated metabolic abnormalities are involved in the pathogenesis of the disease.
描述妊娠晚期正常孕妇和子痫前期孕妇血清内脂素水平的变化。
招募27例子痫前期孕妇。28例妊娠晚期正常孕妇作为妊娠对照组，28例健康非妊娠妇女作为非妊娠对照组。采用酶联免疫吸附测定法测量血清内脂素水平。
非妊娠对照组、妊娠对照组和子痫前期组血清内脂素的均值分别为626.4±45.5 ng/ml（均值±标准误）、695.9±92.5 ng/ml和308.3±80.0 ng/ml，组间差异有统计学意义（p<0.001）。与非妊娠对照组（p=0.004）和妊娠对照组（p<0.001）相比，子痫前期组内脂素水平显著降低。重度子痫前期患者血清内脂素水平显著低于轻度子痫前期患者（114.6±80.9对425.2±122.1 ng/ml，p=0.037）。
子痫前期患者内脂素水平降低，提示内脂素及脂肪因子相关的代谢异常参与了该病的发病机制。
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