Fasshauer M, Blüher M, Stumvoll M, Tönessen P, Faber R, Stepan H
Department of Internal Medicine III, University of Leipzig, Germany.
Clin Endocrinol (Oxf). 2007 Mar;66(3):434-9. doi: 10.1111/j.1365-2265.2007.02751.x.
There is compelling evidence that insulin resistance may play a pivotal role in the development of pregnancy complications including pre-eclampsia and intrauterine growth restriction (IUGR). As dysregulation of visfatin and adiponectin is found in insulin resistance, both adipokines might contribute to pregnancy disorders.
Plasma levels of visfatin and adiponectin were quantified in second-trimester pregnancies with abnormal uterine perfusion and in third-trimester pregnancies with IUGR as compared to healthy controls.
Mean plasma adiponectin levels were significantly increased in women with pathological perfusion (7078 +/- 789 ng/ml) as compared to normal uterine perfusion (4481 +/- 1183 ng/ml) (P < 0.05) whereas visfatin plasma concentrations were not different between these groups. Visfatin levels were significantly elevated in women with IUGR (140.1 +/- 10 ng/ml) as compared to patients with normal outcome (65.5 +/- 11 ng/ml) (P < 0.05). By contrast, adiponectin plasma concentrations were not significantly altered in women with IUGR.
Our data support the view that the adipokines visfatin and adiponectin are differentially regulated in pregnancy complications.
有确凿证据表明，胰岛素抵抗可能在包括先兆子痫和宫内生长受限（IUGR）在内的妊娠并发症的发生发展中起关键作用。由于在胰岛素抵抗中发现内脂素和脂联素失调，这两种脂肪因子可能都与妊娠疾病有关。
与健康对照组相比，对子宫灌注异常的孕中期孕妇和患有IUGR的孕晚期孕妇的血浆内脂素和脂联素水平进行定量分析。
与子宫灌注正常的孕妇（4481±1183 ng/ml）相比，病理灌注孕妇的平均血浆脂联素水平显著升高（7078±789 ng/ml）（P<0.05），而两组之间的血浆内脂素浓度没有差异。与结局正常的患者（65.5±11 ng/ml）相比，IUGR患者的内脂素水平显著升高（140.1±10 ng/ml）（P<0.05）。相比之下，IUGR患者的血浆脂联素浓度没有显著变化。
我们的数据支持这样一种观点，即脂肪因子内脂素和脂联素在妊娠并发症中受到不同的调节。
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