妊娠晚期子痫前期和血压正常孕妇的妊娠相关血浆蛋白A和C反应蛋白水平
Pregnancy-associated plasma protein-A and C-reactive protein levels in pre-eclamptic and normotensive pregnant women at third trimester.
作者信息
Deveci Koksal, Sogut Erkan, Evliyaoglu Osman, Duras Nuriye
机构信息
Department of Biochemistry and Clinical Biochemistry, Ataturk Training Hospital, Izmir, Turkey.
出版信息
J Obstet Gynaecol Res. 2009 Feb;35(1):94-8. doi: 10.1111/j.1447-0756.2008.00835.x.
AIM
The aim of this study was to determine the levels of plasma pregnancy-associated plasma protein-A (PAPP-A) and C-reactive protein (CRP) in pre-eclampsia and their association with the mean arterial blood pressure (MAP).
MATERIAL AND METHODS
Sixty-seven women with pre-eclampsia symptoms were matched with 56 normal pregnant controls for gestational age, maternal age and parity. Both of the groups were third trimester. PAPP-A and CRP were measured in serum using chemiluminescence assay and nephelometry, respectively.
RESULTS
Maternal serum levels of PAPP-A and CRP were increased in women with pre-eclampsia compared to controls. There were significant correlations between MAP and CRP (r = 0.372, P = 0.002) and MAP and PAPP-A parameters (r = 0.301, P = 0.013) in pregnancies complicated with pre-eclampsia. PAPP-A had no correlation with CRP in patients with pre-eclampsia and in normotensive pregnant women.
CONCLUSIONS
We found higher levels of PAPP-A and CRP and the presence of a good correlation between CRP and MAP in pre-eclampsia.
目的
本研究旨在测定子痫前期患者血浆妊娠相关血浆蛋白-A（PAPP-A）和C反应蛋白（CRP）水平及其与平均动脉压（MAP）的相关性。
材料与方法
选取67例有子痫前期症状的孕妇，按照孕周、产妇年龄及产次与56例正常孕妇对照组进行匹配。两组均处于孕晚期。分别采用化学发光法和比浊法测定血清中的PAPP-A和CRP。
结果
与对照组相比，子痫前期患者母体血清中PAPP-A和CRP水平升高。在合并子痫前期的妊娠中，MAP与CRP（r = 0.372，P = 0.002）以及MAP与PAPP-A参数（r = 0.301，P = 0.013）之间存在显著相关性。子痫前期患者及血压正常的孕妇中，PAPP-A与CRP无相关性。
结论
我们发现子痫前期患者PAPP-A和CRP水平较高，且CRP与MAP之间存在良好的相关性。
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