Wilkinson S M, English J S
Department of Dermatology, North Staffordshire Hospital Centre, Hartshill, Stoke-on-Trent, UK.
Contact Dermatitis. 1991 Sep;25(3):178-81. doi: 10.1111/j.1600-0536.1991.tb01824.x.
11 patients, positive to tixocortol pivalate on patch testing, were tested intradermally with a variety of hydrocortisone analogues. Substitution at the C21 position had no effect on the occurrence of positive reactions to hydrocortisone, whereas alteration of any of the carbon rings significantly reduced the number of positive reactions. We suggest that the C17 side chain is involved in protein binding and subsequent presentation of antigenic sites on the carbon rings.
11名斑贴试验对特戊酸替可的松呈阳性的患者，用多种氢化可的松类似物进行了皮内试验。在C21位进行取代对氢化可的松阳性反应的发生没有影响，而任何一个碳环的改变都显著减少了阳性反应的数量。我们认为C17侧链参与了蛋白质结合以及随后碳环上抗原位点的呈现。
