微粒体环氧化物水解酶基因型与头颈癌风险
Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer.
作者信息
Lacko Martin, Roelofs Hennie M J, Te Morsche Rene H M, Voogd Adri C, Oude Ophuis Michael B, Peters Wilbert H M, Manni Johannes J
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Maastricht, Maastricht, The Netherlands.
出版信息
Head Neck. 2008 Jul;30(7):836-44. doi: 10.1002/hed.20781.
BACKGROUND
Microsomal epoxide hydrolase (mEH) is an enzyme involved in the metabolism of (pre)carcinogens in tobacco smoke. We investigated whether functional genetic polymorphisms in mEH may have a risk-modifying effect on head and neck carcinogenesis.
METHODS
Blood from 429 patients with oral, pharyngeal, and laryngeal carcinoma and 419 healthy subjects was investigated for mEH polymorphisms.
RESULTS
Logistic regression analysis did not show differences in mEH genotype distributions between patients and controls, when categorized according to predicted mEH enzyme activity. Also no differences were found when evaluated according to tumor localization, sex, or tobacco consumption. A significantly higher incidence of the 139Arg/Arg variant was found in patients with hypopharyngeal carcinoma compared with controls (OR = 4.39, 95% CI = 1.45 to 13.35).
CONCLUSION
In contrast to earlier reports, we could not demonstrate a risk-modifying effect of genetic polymorphisms in mEH on head and neck carcinogenesis, except for the predicted high activity variant in patients with hypopharyngeal carcinoma.
背景
微粒体环氧化物水解酶（mEH）是一种参与烟草烟雾中（前）致癌物代谢的酶。我们研究了mEH的功能性基因多态性是否可能对头颈部致癌作用产生风险调节效应。
方法
对429例口腔、咽和喉癌患者及419例健康受试者的血液进行mEH多态性检测。
结果
根据预测的mEH酶活性进行分类时，逻辑回归分析未显示患者与对照组之间mEH基因型分布存在差异。根据肿瘤定位、性别或烟草消费量进行评估时也未发现差异。与对照组相比，下咽癌患者中139Arg/Arg变异体的发生率显著更高（比值比=4.39，95%可信区间=1.45至13.35）。
结论
与早期报告相反，除了下咽癌患者中预测的高活性变异体外，我们无法证明mEH基因多态性对头颈部致癌作用具有风险调节效应。
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