烟草烟雾致癌物解毒酶UGT1A7的基因多态性与头颈癌风险
Genetic polymorphisms in the tobacco smoke carcinogens detoxifying enzyme UGT1A7 and the risk of head and neck cancer.
作者信息
Lacko Martin, Roelofs Hennie M J, te Morsche Rene H M, Voogd Adri C, Ophuis Michael B Oude, Peters Wilbert H M, Manni Johannes J
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Maastricht, Maastricht, The Netherlands.
出版信息
Head Neck. 2009 Oct;31(10):1274-81. doi: 10.1002/hed.21090.
BACKGROUND
UGT1A7 is an enzyme involved in the metabolism of (pre)carcinogens present in tobacco smoke. We investigated whether genetic polymorphisms in UGT1A7, with predicted altered enzyme activity, may have a risk-modifying effect on head and neck carcinogenesis.
METHODS
Blood samples from 427 patients with oral, pharyngeal, and laryngeal carcinoma and 420 healthy control subjects were investigated for UGT1A7 polymorphisms. Based on these polymorphisms, patients and controls were divided according to predicted enzyme activity (low, intermediate, high).
RESULTS
Logistic regression analysis showed a significant increased distribution of predicted high activity UGT1A7 polymorphisms among the patients (OR:1.44; 95% CI: 1.07-1.93). Stratified analyses demonstrated that high activity UGT1A7 polymorphisms were even more significantly present in patients with laryngeal cancer, older patients, heavy smokers, and heavy drinkers when compared with the control subjects.
CONCLUSIONS
Predicted high activity UGT1A7 polymorphisms were significantly associated with an increased risk of head and neck cancer.
背景
UGT1A7是一种参与烟草烟雾中（前）致癌物代谢的酶。我们研究了UGT1A7基因多态性（预测其酶活性改变）是否可能对头颈部致癌作用产生风险修正效应。
方法
对427例口腔、咽和喉癌患者及420例健康对照者的血样进行UGT1A7基因多态性检测。根据这些多态性，将患者和对照者按预测的酶活性（低、中、高）进行分组。
结果
逻辑回归分析显示，患者中预测的UGT1A7高活性基因多态性分布显著增加（比值比：1.44；95%置信区间：1.07 - 1.93）。分层分析表明，与对照者相比，喉癌患者、老年患者、重度吸烟者和重度饮酒者中UGT1A7高活性基因多态性更为显著。
结论
预测的UGT1A7高活性基因多态性与头颈部癌症风险增加显著相关。
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