应激蛋白HSP27和HSP70i可预测非小细胞肺癌的生存率。
Stress proteins HSP27 and HSP70i predict survival in non-small cell lung carcinoma.
作者信息
Malusecka Ewa, Krzyzowska-Gruca Stefania, Gawrychowski Jacek, Fiszer-Kierzkowska Anna, Kolosza Zofia, Krawczyk Zdzislaw
机构信息
Department of Tumor Biology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Branch Gliwice, 44-101 Gliwice, Poland.
出版信息
Anticancer Res. 2008 Jan-Feb;28(1B):501-6.
BACKGROUND
The expression pattern of stress (heat shock) proteins (HSPs) in cancer cells is frequently different from that observed in normal cells; most often some stress-inducible HSPs are constitutively and highly expressed. The objective of this study was to determine the prognostic significance of stress proteins HSP70i and HSP27 in non-small cell lung carcinoma (NSCLC).
MATERIALS AND METHODS
An immunohistochemical procedure that enables unambiguous detection of HSP70i protein was used.
RESULTS
Strong HSP70i staining showed a survival advantage, although multivariate analysis did not confirm this result. There was an evident correlation between HSP27 overexpression and survival of patients and the results were confirmed by multivariate analysis: 70% of patients with HSP27-negative tumors died within one year after the surgery.
CONCLUSION
Our data suggest that HSP27 and HSP70i positivity may represent a favorable prognostic factor in NSCLC.
背景
癌细胞中应激（热休克）蛋白（HSPs）的表达模式通常与正常细胞中观察到的不同；最常见的是一些应激诱导型HSPs组成性高表达。本研究的目的是确定应激蛋白HSP70i和HSP27在非小细胞肺癌（NSCLC）中的预后意义。
材料与方法
采用一种能明确检测HSP70i蛋白的免疫组织化学方法。
结果
HSP70i强染色显示出生存优势，尽管多因素分析未证实这一结果。HSP27过表达与患者生存率之间存在明显相关性，多因素分析证实了该结果：70%的HSP27阴性肿瘤患者在手术后一年内死亡。
结论
我们的数据表明，HSP27和HSP70i阳性可能是非小细胞肺癌的一个有利预后因素。
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