Hoffmann Peter R, Berry Marla J
Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, HI 96813, USA.
Mol Nutr Food Res. 2008 Nov;52(11):1273-80. doi: 10.1002/mnfr.200700330.
Selenium (Se) is a potent nutritional antioxidant that carries out biological effects through its incorporation into selenoproteins. Given the crucial roles that selenoproteins play in regulating reactive oxygen species (ROS) and redox status in nearly all tissues, it is not surprising that dietary Se strongly influences inflammation and immune responses. The notion that Se "boosts" the immune system has been supported by studies involving aging immunity or protection against certain pathogens. However, studies examining the effects of Se status on other types of immunity such as antiparasitic responses or allergic asthma have suggested more Se may not always be beneficial. In this review, we summarize and compare the available data regarding how the levels of Se affect different types of immunity. Overall, determining how Se intake differentially affects various types of immune responses and dissecting the mechanisms by which this occurs will lead to a better utilization of Se-supplementation for human diseases involving the immune system.
硒（Se）是一种强大的营养抗氧化剂，通过掺入硒蛋白发挥生物学作用。鉴于硒蛋白在几乎所有组织中调节活性氧（ROS）和氧化还原状态方面发挥着关键作用，饮食中的硒强烈影响炎症和免疫反应也就不足为奇了。硒“增强”免疫系统这一观点得到了涉及衰老免疫或预防某些病原体的研究支持。然而，研究硒状态对其他类型免疫（如抗寄生虫反应或过敏性哮喘）的影响表明更多的硒并不总是有益的。在这篇综述中，我们总结并比较了关于硒水平如何影响不同类型免疫的现有数据。总体而言，确定硒摄入量如何不同地影响各种类型的免疫反应并剖析其发生机制，将有助于更好地利用补充硒来治疗涉及免疫系统的人类疾病。
