Długosz Anna, Wróblewski Marcin, Błaszak Błażej, Szulc Joanna
Department of Food Industry Technology and Engineering, Faculty of Chemical Technology and Engineering, Bydgoszcz University of Science and Technology, 3 Seminaryjna St., 85-326 Bydgoszcz, Poland.
Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 24 Karłowicza St., 85-092 Bydgoszcz, Poland.
Int J Mol Sci. 2025 Jan 18;26(2):808. doi: 10.3390/ijms26020808.
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and interaction, alongside repetitive behaviors, and atypical sensory-motor patterns. The growing prevalence of ASD has driven substantial advancements in research aimed at understanding its etiology, preventing its onset, and mitigating its impact. This ongoing effort necessitates continuous updates to the body of knowledge and the identification of previously unexplored factors. The present study addresses this need by examining the roles of nutrition, oxidative stress, and trace elements in the pathophysiology of ASD. In this review, an overview is provided of the key dietary recommendations for individuals with ASD, including gluten-free and casein-free (GFCF) diets, ketogenic diets (KDs), and other nutritional interventions. Furthermore, it explores the involvement of oxidative stress in ASD and highlights the significance of trace elements in maintaining neuropsychiatric health. The impact of these factors on molecular and cellular mechanisms was discussed, alongside therapeutic strategies and their efficacy in managing ASD.
自闭症谱系障碍（ASD）是一种神经发育障碍，其特征是社交沟通和互动缺陷，同时伴有重复行为和非典型的感觉运动模式。ASD患病率的不断上升推动了旨在了解其病因、预防其发病以及减轻其影响的研究取得了重大进展。这项持续的工作需要不断更新知识体系并识别以前未被探索的因素。本研究通过研究营养、氧化应激和微量元素在ASD病理生理学中的作用来满足这一需求。在这篇综述中，概述了针对ASD患者的关键饮食建议，包括无麸质和无酪蛋白（GFCF）饮食、生酮饮食（KDs）以及其他营养干预措施。此外，还探讨了氧化应激在ASD中的作用，并强调了微量元素在维持神经精神健康方面的重要性。讨论了这些因素对分子和细胞机制的影响，以及治疗策略及其在管理ASD方面的疗效。
