利用营养物质和天然产物进行可持续的抗衰老药物研发。
Harnessing nutrients and natural products for sustainable drug development against aging.
作者信息
Ding Fuan, Yu Ying, Zhang Yan, Wei Shibo, Han Jung Ho, Li Zhuo, Jiang Hong-Bo, Ryu Dongryeol, Park Wonyoung, Ha Ki-Tae, Geng Li
机构信息
Department of Vascular Surgery, The Second Hospital of Jilin University, Changchun, China.
Department of Surgery, Changchun University of Chinese Medicine, Changchun, China.
出版信息
Front Pharmacol. 2025 Apr 28;16:1579266. doi: 10.3389/fphar.2025.1579266. eCollection 2025.
Developing treatments for age-related diseases requires cost-effective and efficient approaches. Nutrients and natural metabolites offer safer alternatives to synthetic drugs. Aging increases the need for solutions that protect health and repair cells. Recent studies show that nutrients and natural products reduce oxidative stress, regulate metabolism, and influence longevity-related genes. This review focuses on vitamins, minerals, antioxidants, and natural products that improve healthspan and combat aging. It also discusses challenges such as standardization, clinical validation, and regulatory approval. Finally, emerging trends, such as personalized nutrition and advanced delivery systems, highlight the potential of these metabolites for addressing aging.
开发与年龄相关疾病的治疗方法需要具有成本效益且高效的方法。营养素和天然代谢产物为合成药物提供了更安全的替代品。衰老增加了对保护健康和修复细胞的解决方案的需求。最近的研究表明，营养素和天然产物可减少氧化应激、调节新陈代谢并影响与长寿相关的基因。这篇综述重点关注改善健康寿命和对抗衰老的维生素、矿物质、抗氧化剂和天然产物。它还讨论了标准化、临床验证和监管批准等挑战。最后，个性化营养和先进递送系统等新兴趋势凸显了这些代谢产物在应对衰老方面的潜力。
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