Deconinck E, Sohier J, De Scheerder I, Van den Mooter G
Ziscoat N.V., Interleuvenlaan 62 Zone 2, B-3001 Heverlee, Belgium.
J Pharm Sci. 2008 Dec;97(12):5047-60. doi: 10.1002/jps.21356.
This review focuses on the pharmaceutical aspects of the development of drug eluting stents. It discusses the different processes that can be used to obtain a controlled release of a drug from the stent as well as the coatings therefore applied. Results obtained for stents already available on the market or in a far stage of development are discussed. In a final part possible future research areas as well as expected new evolutions in the design of drug eluting stents are presented.
本综述聚焦于药物洗脱支架研发中的药学方面。它讨论了可用于实现药物从支架中可控释放的不同工艺以及由此应用的涂层。文中还讨论了已在市场上可得或处于研发后期阶段的支架所取得的结果。在最后一部分，介绍了药物洗脱支架设计中可能的未来研究领域以及预期的新进展。
