School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
J Control Release. 2014 Nov 10;193:188-201. doi: 10.1016/j.jconrel.2014.05.011. Epub 2014 May 17.
This paper reviews the latest research and development of drug-eluting stents. The emphasis is on coronary stenting, and both biostable and bioerodible stents are covered in this review. The advantages and shortcomings of the bioactive molecules used in these stents are analyzed, along with the rationale for using bioerodible coatings. The overall emphasis is on the performance of these stents in the clinic. Based on the evaluation of the different stent types, we conclude that fully-erodible stents with a coating of antiproliferative drug will slowly gain market share in the near future, and that the search for a more selective anti-proliferative compound will continue. Dual-drug eluting stents (DDESs) will have their market share but possibly a much smaller one than that for single-drug eluting stents due to the complexities and costs of DDES unless significantly superior performance is demonstrated in the clinic.
本文综述了药物洗脱支架的最新研究进展。重点介绍了冠状动脉支架，包括生物稳定支架和可生物降解支架。本文分析了这些支架中使用的生物活性分子的优缺点，以及使用可生物降解涂层的原理。全文重点关注这些支架在临床中的性能。基于对不同支架类型的评估，我们得出结论，具有抗增殖药物涂层的完全可降解支架将在不久的将来逐渐获得市场份额，而寻找更具选择性的抗增殖化合物的研究将继续进行。双药物洗脱支架（DDES）将有一定的市场份额，但由于 DDES 的复杂性和成本，其市场份额可能比单药物洗脱支架小得多，除非在临床中表现出明显更优的性能。
