Langenberger Herbert, Friedrich Klaus, Plank Christina, Matzek Wolfgang, Wolf Florian, Storto Maria Luigia, Schaefer-Prokop Cornelia, Herold Christian
Department of Radiology, Vienna General Hospital, Medical University, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
Eur J Radiol. 2009 Jun;70(3):579-88. doi: 10.1016/j.ejrad.2008.01.058. Epub 2008 Apr 1.
To compare iomeprol 400 and iodixanol 320 in pulmonary artery MDCTA in subjects with suspected pulmonary embolism.
Eighty randomized subjects received equi-iodine intravenous doses (48 g) of iomeprol 400 (n=40) or iodixanol 320 (n=40), via power injector at 4 mL/s. Four-row (35 subjects) and 64-row (45 subjects) scanners were used. Lumen attenuation was determined on-site and by two off-site blinded readers in the main, lobar, segmental and subsegmental pulmonary arteries. Statistical comparison between groups was performed for demographics and lumen attenuation.
There were no between-group differences (p>0.05) in demographics. Pulmonary artery attenuation was significantly (p<or=0.03) higher with iomeprol 400 for all readers. Attenuation quality was excellent in more patients after iomeprol 400 than after iodixanol-320 (80% vs. 62.5%; 82.5% vs. 77.5%; off-site readers 1 and 2, respectively). No safety concerns were noted.
The greater iodine delivery rate achievable with iomeprol 400 compared to iodixanol-320 at equi-iodine dose and injection rate permits consistently greater attenuation at all levels of the pulmonary arterial tree.
比较碘海醇400和碘克沙醇320在疑似肺栓塞患者肺动脉MDCTA中的应用。
80名随机分组的受试者通过注射泵以4 mL/s的速度静脉注射等碘剂量（48 g）的碘海醇400（n = 40）或碘克沙醇320（n = 40）。使用了四排（35名受试者）和64排（45名受试者）扫描仪。在主肺动脉、叶肺动脉、段肺动脉和亚段肺动脉中，现场及两名非现场盲法阅片者测定管腔衰减。对两组的人口统计学数据和管腔衰减进行统计学比较。
两组在人口统计学数据上无差异（p>0.05）。对于所有阅片者，碘海醇400组的肺动脉衰减显著更高（p≤0.03）。碘海醇400组中衰减质量优秀的患者比碘克沙醇320组更多（分别为80%对62.5%；82.5%对77.5%；分别为非现场阅片者1和2）。未发现安全问题。
在等碘剂量和注射速率下，碘海醇400比碘克沙醇320可实现更高的碘输送率，从而在肺动脉树的所有水平上始终实现更大的衰减。
