Department of Medical Research, Chang Gung Memorial Hospital at Kaohsiung, Chang Gung University, Kaohsiung 833, Taiwan.
Br J Sports Med. 2009 Oct;43(11):845-50. doi: 10.1136/bjsm.2007.043562. Epub 2008 Apr 2.
Exercise has been shown to be beneficial in the treatment of type 2 diabetes mellitus (DM); its benefit to immune function, however, remains to be determined.
This study investigated the effect of a 12-week course of Tai Chi Chuan (TCC) exercise on T cell helper (Th) reaction in patients with type 2 DM.
A case-control study was performed in 30 pairs of patients with type 2 DM and normal age-matched adults. Fasting blood glucose, HbA1c, mediators (interleukin (IL)-12, IL-4 and transforming growth factor (TGF)beta) and transcription factors (T-bet, GATA-3 and FoxP3) of Th1/Th2/T regulatory (Treg) reaction were measured before and after a 12-week TCC exercise programme.
Fasting glucose and HbA1c levels in the patients with type 2 DM were significantly higher than in age-matched controls before exercise. After TCC exercise, HbA1c levels in patients with type 2 DM significantly decreased (7.59 (0.32)% vs 7.16 (0.22)%; p = 0.047) and blood levels of IL-12 increased significantly (5.96 (1.10) vs 12.96 (3.07); p = 0.035). To study the molecular Th1/Th2/Treg reaction, patients with type 2 DM were found to have lower T-bet but not GATA-3 or FoxP3 expression than normal controls before TCC exercise. After the 12-week TCC exercise T-bet expression significantly increased in patients with type 2 DM.
A 12-week TCC exercise programme decreases HbA1c levels along with an increase in the Th1 reaction. A combination of TCC with medication may provide an even better improvement in both metabolism and immunity of patients with type 2 DM.
运动已被证明对 2 型糖尿病（DM）的治疗有益；然而，其对免疫功能的益处仍有待确定。
本研究调查了 12 周太极拳（TCC）运动对 2 型糖尿病患者 T 细胞辅助（Th）反应的影响。
对 30 对 2 型糖尿病患者和年龄匹配的正常成年人进行病例对照研究。在 TCC 运动方案 12 周前后，测量空腹血糖、HbA1c、介质（白细胞介素（IL）-12、IL-4 和转化生长因子（TGF）β）和 Th1/Th2/T 调节（Treg）反应的转录因子（T-bet、GATA-3 和 FoxP3）。
2 型糖尿病患者的空腹血糖和 HbA1c 水平明显高于运动前的年龄匹配对照组。TCC 运动后，2 型糖尿病患者的 HbA1c 水平明显下降（7.59（0.32）%比 7.16（0.22）%；p=0.047），IL-12 血水平明显升高（5.96（1.10）比 12.96（3.07）；p=0.035）。为了研究分子 Th1/Th2/Treg 反应，在 TCC 运动前，与正常对照组相比，2 型糖尿病患者的 T-bet 表达较低，但 GATA-3 或 FoxP3 表达没有差异。在 12 周的 TCC 运动后，2 型糖尿病患者的 T-bet 表达明显增加。
12 周 TCC 运动方案可降低 HbA1c 水平，同时增加 Th1 反应。TCC 与药物联合治疗可能会在改善 2 型糖尿病患者的代谢和免疫方面提供更好的效果。
