Xiang Lijuan, Su Zhanguo
Chongqing Preschool Education College, Chongqing, 404047, China.
Department of Physical Education, Chengdu Normal University, 611130 Chengdu, China.
Eur J Med Res. 2025 Jul 26;30(1):677. doi: 10.1186/s40001-025-02927-3.
The development of cardiovascular diseases (CVD) is intricate and has many contributing factors, with inflammation being a key player. Inflammasomes are clusters of proteins that are triggered in two stages when the body is exposed to infection or injury. The proinflammatory proteins IL-1β and -18 are discharged as soon as they are activated. In the recent years, the increasing evidence pointing to a connection between the activation of inflammasomes and the development of heart disease has gained significant support. Compared with medication, exercise is a significantly potent method for averting and managing CVD. New evidence indicates that taking part in exercise can have a beneficial influence on cardiovascular wellness by decreasing the activity of the NLRP3 inflammasome and mitigating pyroptosis. This article explores the factors that can stimulate the NLRP3 inflammasome and its harmful impact on cardiovascular disease, highlighting the significance of regular exercise in managing this condition through its ability to decrease NLRP3 inflammasome activation and subsequent pyroptosis. It also suggests considering exercise as a core component in developing new treatment methods.
心血管疾病（CVD）的发展错综复杂，有许多促成因素，炎症是关键因素。炎性小体是蛋白质簇，当身体受到感染或损伤时，会分两个阶段被触发。促炎蛋白IL-1β和IL-18一旦被激活就会释放出来。近年来，越来越多的证据表明炎性小体的激活与心脏病的发展之间存在联系，这一观点得到了有力支持。与药物治疗相比，运动是预防和管理心血管疾病的一种显著有效的方法。新证据表明，参加运动可以通过降低NLRP3炎性小体的活性和减轻细胞焦亡，对心血管健康产生有益影响。本文探讨了可刺激NLRP3炎性小体的因素及其对心血管疾病的有害影响，强调了定期运动通过降低NLRP3炎性小体激活及随后的细胞焦亡来管理这种疾病的重要性。文章还建议将运动视为开发新治疗方法的核心组成部分。
