原发性胆汁性肝硬化（PBC）和隐源性慢性肝病绝经后女性的性激素变化

Sex hormone changes in post-menopausal women with primary biliary cirrhosis (PBC) and with cryptogenic chronic liver disease.

作者信息

Floreani A, Titta M, Plebani M, Faggian D, Chiaramonte M, Naccarato R

机构信息

Department of Gastroenterology R. Farini, University of Padova.

出版信息

Clin Exp Obstet Gynecol. 1991;18(4):229-34.

PMID:1838720

Abstract

Sex hormones and sex hormone binding globulin (SHBG) have been studied in 32 female post-menopausal patients (16 with Primary Biliary Cirrhosis (PBC) and 16 with cryptogenic chronic liver disease (CLD). Dehydroepiandrosterone-sulfate (DHEA-S) serum levels were significantly higher in PBC compared to CLD subjects (p less than 0.005). In PBC DHEA-S concentration was higher in precirrhotic than in cirrhotic patients (p less than 0.02). SHBG was raised in both PBC and CLD patients but higher in CLD compared to PBC subjects (p less than 0.002). PBC reveals a sex hormone pattern similar to post-menopausal subjects with breast cancer. These results suggest that sex hormone alteration is present in females with different types of liver disease, but the metabolic pattern is not due to liver disease per se.

摘要

对32名绝经后女性患者（16例原发性胆汁性肝硬化（PBC）患者和16例隐源性慢性肝病（CLD）患者）的性激素和性激素结合球蛋白（SHBG）进行了研究。与CLD受试者相比，PBC患者的硫酸脱氢表雄酮（DHEA-S）血清水平显著更高（p<0.005）。在PBC患者中，肝硬化前期患者的DHEA-S浓度高于肝硬化患者（p<0.02）。PBC和CLD患者的SHBG均升高，但CLD患者的SHBG高于PBC受试者（p<0.002）。PBC患者的性激素模式与绝经后乳腺癌患者相似。这些结果表明，不同类型肝病的女性存在性激素改变，但代谢模式并非由肝病本身所致。