Phillips G B
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA.
Eur J Endocrinol. 1996 Feb;134(2):201-6. doi: 10.1530/eje.0.1340201.
Previous reports of a correlation between serum dehydroepiandrosterone sulfate (DHEAS) and testosterone in both men and women have led to the suggestion that adrenal and gonadal secretion are related. In the present study, the correlation of DHEAS with testosterone and free testosterone (FT) in both normal men and women was tested. Androstenedione, estradiol, sex hormone binding globulin (SHBG), and insulin were also measured and their correlations determined. All correlations were controlled for age and body mass index. In the men in the study, DHEAS did not correlate with testosterone or FT but correlated strongly with androstenedione. In the women, DHEAS correlated strongly with testosterone, FT, and androstenedione; androstenedione in turn correlated strongly with testosterone and FT. DHEAS showed no correlations with estradiol, SHBG, or insulin in the men or women. The lack of a correlation between DHEAS and testosterone in normal men is consistent with the independent secretion of these hormones by the adrenal and testis, respectively. The finding of a strong DHEAS-testosterone correlation in normal women may be explained by parallel adrenal secretion in response to trophic stimuli, i.e., without invoking an adrenal-gonadal interaction.
先前有关男性和女性血清硫酸脱氢表雄酮（DHEAS）与睾酮之间相关性的报告表明，肾上腺和性腺分泌之间存在关联。在本研究中，检测了正常男性和女性中DHEAS与睾酮及游离睾酮（FT）之间的相关性。同时测量了雄烯二酮、雌二醇、性激素结合球蛋白（SHBG）和胰岛素，并确定了它们之间的相关性。所有相关性均对年龄和体重指数进行了校正。在本研究的男性中，DHEAS与睾酮或FT无相关性，但与雄烯二酮密切相关。在女性中，DHEAS与睾酮、FT和雄烯二酮密切相关；雄烯二酮又与睾酮和FT密切相关。在男性或女性中，DHEAS与雌二醇、SHBG或胰岛素均无相关性。正常男性中DHEAS与睾酮缺乏相关性，这与肾上腺和睾丸分别独立分泌这些激素相一致。正常女性中DHEAS与睾酮密切相关这一发现，可能是由于对营养刺激的平行肾上腺分泌所致，即无需涉及肾上腺-性腺相互作用。
