异戊烯基-1,2-萘二酚的细胞毒性抗肿瘤衍生物。

Cytotoxic-antineoplastic derivatives of prenyl-1,2-naphthohydroquinone.

作者信息

Molinari Aurora, Oliva Alfonso, Ojeda Claudia, del Corral José M Miguel, Castro M Angeles, Cuevas Carmen, San Feliciano Arturo

机构信息

Instituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.

出版信息

Arch Pharm (Weinheim). 2008 May;341(5):301-6. doi: 10.1002/ardp.200700259.

DOI:10.1002/ardp.200700259

PMID:18389518

Abstract

Several new prenyl-1,2-naphthohydroquinone derivatives have been prepared by chemical modifications of Diels-Alder products which were obtained from cycloaddition of alpha-myrcene to 1,2-benzoquinone and then evaluated in vitro for their cytotoxic activity against A-549 lung carcinoma, HT-29 colon carcinoma, and MB-231 breast adeno-carcinoma culture cells. Most of them exhibited GI50 values in the microM-concentration level.

摘要

通过对狄尔斯-阿尔德反应产物进行化学修饰，制备了几种新的异戊烯基-1,2-萘氢醌衍生物。这些产物是由α-月桂烯与1,2-苯醌环加成得到的，然后对其针对A-549肺癌、HT-29结肠癌和MB-231乳腺腺癌培养细胞的细胞毒性活性进行了体外评估。其中大多数在微摩尔浓度水平上表现出半数生长抑制浓度（GI50）值。