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海洋源生物活性的类异戊烯基和三萜基醌/对苯二酚。

Bioactive Prenyl- and Terpenyl-Quinones/Hydroquinones of Marine Origin .

机构信息

Department of Pharmaceutical Sciences, Pharmaceutical Chemistry Section, CIETUS/IBSAL, Faculty of Pharmacy, University of Salamanca, E-37007 Salamanca, Spain.

出版信息

Mar Drugs. 2018 Aug 21;16(9):292. doi: 10.3390/md16090292.

Abstract

The sea is a rich source of biological active compounds, among which terpenyl-quinones/hydroquinones constitute a family of secondary metabolites with diverse pharmacological properties. The chemical diversity and bioactivity of those isolated from marine organisms in the last 10 years are summarized in this review. Aspects related to synthetic approaches towards the preparation of improved bioactive analogues from inactive terpenoids are also outlined.

摘要

海洋是生物活性化合物的丰富来源,其中萜烯基-醌/对苯二酚构成了一类具有多种药理性质的次生代谢产物。本文综述了过去 10 年从海洋生物中分离得到的萜烯基-醌/对苯二酚类化合物的化学多样性和生物活性。本文还概述了从无活性萜类化合物制备改进的生物活性类似物的合成方法方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f1e/6165040/4623d561686c/marinedrugs-16-00292-g001.jpg

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