Glycoprotein expression in mouse cerebellum: effects of inhibitors of N-linked glycosylation.
作者信息
Carroll M, Bird M M
机构信息
Department of Biochemistry, Queen Mary and Westfield College, London, England.
出版信息
Int J Biochem. 1991;23(11):1285-91. doi: 10.1016/0020-711x(91)90229-g.
PMID:1838985
Abstract
- Explants of cerebellum from foetal mouse were cultured in vitro for 10 days in the presence of one of 4 inhibitors of N-linked glycosylation (castanospermine, deoxymannojirimycin, swainsonine, and tunicamycin). 2. The effects of the inhibitors were compared with respect to: (a) the activity of enzymes involved in glycoprotein biosynthesis and degradation; (b) the expression of N-linked glycoproteins; (c) the morphology and ultrastructure of the treated cerebellar explants.
摘要
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