Gomutbutra Vorapin
Department of Obstetrics and Gynecology Unit, Nakornping Hospital, Chiang Mai, Thailand.
J Med Assoc Thai. 2008 Feb;91(2):142-5.
The HIV infected pregnancy delivered at Nakornping Hospital was common. To reduce and prevent HIV infection in pregnancy and perinatal transmission, the understanding of characteristics of HIV pregnancy and neonatal infective outcome were needed for proper strategy and policy making.
To study the characteristics of HIV pregnancy and neonatal infective outcome in a hospital in the northern part of Thailand.
This retrospective descriptive study was conducted at the Department of Obstetrics and Gynecology Unit, Nakornping Hospital, Chiang Mai Province, Thailand. Medical records of HIV infected pregnancy from the labor unit during October 2002 and September 2005 was scrutinized. The relevant data of the characteristics of HIV infected mother, pregnancy and neonatal infective outcome were collected and analyzed.
There were 172 HIV infected mothers among 7,872 parturients (2.2%). The mean age was 28.2 years (range 14-44 years). Most of the cases were between 25-29 years (40%). 45 pregnancies (26%) delivered before 37 weeks. About half (50.6%) delivered via cesarean section. 22% of their newborn weighted below 2,500 grams. With antiviral regimen of Navirapine and Zidovudine for both mothers and their neonate the overall perinatal transmission rate was 4%. In mothers having ANC group the transmission rate was 3.2% compared to 11.7% in no ANC group. (X2 = 1.092 p = 0.296 Cl 0.04-1.4) RR of ANC group = 0.274 compare to no ANC.
Many of HIV infected mothers were in the young age group. High preterm labor rate was observed. The no ANC group had about 4 folds infective neonate compared to the ANC group. No antiviral drug during pregnancy in no ANC group may be a factor. This information was vital for strategic ANC planning to prevent and reduce this problem.
在那空平医院分娩的感染艾滋病毒的孕妇很常见。为减少和预防孕期艾滋病毒感染及围产期传播，制定适当的战略和政策需要了解艾滋病毒感染孕妇的特征及新生儿感染结局。
研究泰国北部一家医院中艾滋病毒感染孕妇的特征及新生儿感染结局。
这项回顾性描述性研究在泰国清迈府那空平医院妇产科进行。对2002年10月至2005年9月产房内感染艾滋病毒孕妇的病历进行了仔细审查。收集并分析了感染艾滋病毒母亲的特征、妊娠情况及新生儿感染结局的相关数据。
7872名产妇中有172名感染艾滋病毒的母亲（2.2%）。平均年龄为28.2岁（范围14 - 44岁）。大多数病例年龄在25 - 29岁之间（40%）。45例妊娠（26%）在37周前分娩。约一半（50.6%）通过剖宫产分娩。22%的新生儿体重低于2500克。母亲和新生儿均采用奈韦拉平和齐多夫定的抗病毒方案，总体围产期传播率为4%。接受产前检查（ANC）组母亲的传播率为3.2%，未接受产前检查组为11.7%。（X² = 1.092，p = 0.296，可信区间0.04 - 1.4）与未接受产前检查组相比，接受产前检查组的相对危险度（RR）= 0.274。
许多感染艾滋病毒的母亲年龄较轻。观察到早产率较高。未接受产前检查组感染新生儿的比例是接受产前检查组的约4倍。未接受产前检查组孕期未使用抗病毒药物可能是一个因素。这些信息对于预防和减少这一问题的战略产前检查规划至关重要。
