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Lancet Infect Dis. 2012 May;12(5):388-96. doi: 10.1016/S1473-3099(11)70339-5. Epub 2011 Dec 12.
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Pregnancy outcomes associated with viral hepatitis.与病毒性肝炎相关的妊娠结局。
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Liver Int. 2010 May;30(5):765-70. doi: 10.1111/j.1478-3231.2010.02218.x. Epub 2010 Mar 8.
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Prevalence of chronic hepatitis B virus infection among patients in the HIV Outpatient Study, 1996-2007.1996-2007 年 HIV 门诊研究患者中慢性乙型肝炎病毒感染的流行情况。
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Hepatitis B Prevalence during pregnancy.孕期乙型肝炎患病率。
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孕产妇乙型肝炎病毒合并感染对HIV母婴传播的影响。

Impact of maternal hepatitis B virus coinfection on mother-to-child transmission of HIV.

作者信息

Mave V, Kadam D, Kinikar A, Gupte N, Bhattacharya D, Bharadwaj R, McIntire K, Kulkarni V, Balasubramanian U, Suryavanshi N, Thio C, Deshpande P, Sastry J, Bollinger R, Gupta A, Bhosale R

机构信息

Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India; Johns Hopkins School of Medicine, Baltimore, MD, USA.

出版信息

HIV Med. 2014 Jul;15(6):347-54. doi: 10.1111/hiv.12120. Epub 2014 Jan 14.

DOI:10.1111/hiv.12120
PMID:24422893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4055515/
Abstract

OBJECTIVES

Despite high hepatitis B virus (HBV) endemicity in various resource-limited settings (RLSs), the impact of maternal HIV/HBV coinfection on infant health outcomes has not been defined. We aimed to assess the prevalence of HBV coinfection among HIV-infected pregnant women and its impact on HIV transmission and infant mortality.

METHODS

In this study, the seroprevalence of HBV coinfection was determined among HIV-infected pregnant women enrolled in the Six-Week Extended-Dose Nevirapine (SWEN) India trial. The impact of maternal HIV/HBV coinfection on mother-to-child transmission (MTCT) of HIV and infant mortality was assessed using univariate and multivariate logistic regression analysis.

RESULTS

Among 689 HIV-infected pregnant Indian women, 32 (4.6%) had HBV coinfection [95% confidence interval (CI) 3.4%, 5.3%]. HBV DNA was detectable in 18 (64%) of 28 HIV/HBV-coinfected women; the median HBV viral load was 155 copies/mL [interquartile range (IQR) < 51-6741 copies/mL]. Maternal HIV/HBV coinfection did not increase HIV transmission risk [adjusted odds ratio (aOR) 1.06; 95% CI 0.30, 3.66; P = 0.93]. Increased odds of all-cause infant mortality was noted (aOR 3.12; 95% CI 0.67, 14.57; P = 0.15), but was not statistically significant.

CONCLUSIONS

The prevalence of active maternal HBV coinfection in HIV-infected pregnant women in India was 4.6%. HIV/HBV coinfection was not independently associated with HIV transmission.

摘要

目的

尽管在各种资源有限的环境中乙肝病毒（HBV）流行率很高，但孕产妇HIV/HBV合并感染对婴儿健康结局的影响尚未明确。我们旨在评估HIV感染孕妇中HBV合并感染的患病率及其对HIV传播和婴儿死亡率的影响。

方法

在本研究中，对参加印度六周延长剂量奈韦拉平（SWEN）试验的HIV感染孕妇进行了HBV合并感染的血清流行率测定。使用单因素和多因素逻辑回归分析评估孕产妇HIV/HBV合并感染对HIV母婴传播（MTCT）和婴儿死亡率的影响。

结果

在689名HIV感染的印度孕妇中，32名（4.6%）患有HBV合并感染[95%置信区间（CI）3.4%，5.3%]。在28名HIV/HBV合并感染的女性中，18名（64%）可检测到HBV DNA；HBV病毒载量中位数为155拷贝/mL[四分位间距（IQR）<51-6741拷贝/mL]。孕产妇HIV/HBV合并感染并未增加HIV传播风险[调整优势比（aOR）1.06；95%CI 0.30，3.66；P=0.93]。全因婴儿死亡率的优势比有所增加（aOR 3.12；95%CI 0.67，14.57；P=0.15），但无统计学意义。

结论

印度HIV感染孕妇中活动性孕产妇HBV合并感染的患病率为4.6%。HIV/HBV合并感染与HIV传播无独立相关性。