Gao Jian, Zhou Yu-Chun, Huang Yu-Feng
PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, PLA, Nanjing, Jiangsu 210002, China.
Zhonghua Nan Ke Xue. 2008 Feb;14(2):166-70.
IgY antibodies, also called egg yolk immunoglobulins, are the only immunoglobulins in egg yolk and transferred in the female from serum to egg yolk to confer passive immunity to embryos and neonates. Using hens instead of mammals as the immunization host brings a number of advantages: Eggs are cheap and readily available; antibody levels in yolks are high; IgY isolation is fast and simple; and what is more; IgY neither binds the rheumatoid factor nor reacts to the mammalian complement factor. All these differences make IgY technology more widely applicable, such as in the production of polyclonal antibodies against various antigens, immunodiagnostics and immunotherapy, and many medical areas in both animals and human. IgY also has a good prospect in human immunocontraception.
卵黄抗体（IgY），也称为蛋黄免疫球蛋白，是蛋黄中唯一的免疫球蛋白，由母体从血清转移至蛋黄，为胚胎和新生儿提供被动免疫。使用母鸡而非哺乳动物作为免疫宿主具有诸多优势：鸡蛋价格低廉且易于获取；蛋黄中的抗体水平很高；IgY的分离快速简便；此外，IgY既不与类风湿因子结合，也不与哺乳动物补体因子发生反应。所有这些差异使得IgY技术具有更广泛的应用，例如用于生产针对各种抗原的多克隆抗体、免疫诊断和免疫治疗，以及在动物和人类的许多医学领域。IgY在人类免疫避孕方面也具有良好的前景。
