Zhao Y L, Wang J H, Cheng C P
Department of Physiology, Harbin Medical University.
Sheng Li Xue Bao. 1991 Dec;43(6):580-3.
Isolated ovarian corpus luteal cells and granulosa cells of rat were employed to investigate the effect of alpha-ANP on the secretion of progesterone and estradiol. The contents of the steroid hormones are determined by RIA. The results showed that 0.1-10 ng/ml ANP promoted progesterone production in a dose dependent manner. alpha-ANP also enhanced progesterone production by granulosa cells, but not estradiol. It seems that the effect of alpha-ANP on ovarian steroidogenesis is a direct one.
采用大鼠分离的卵巢黄体细胞和颗粒细胞来研究α-心钠素对孕酮和雌二醇分泌的影响。用放射免疫分析法测定类固醇激素的含量。结果显示，0.1 - 10 ng/ml的心钠素以剂量依赖方式促进孕酮生成。α-心钠素也增强颗粒细胞的孕酮生成，但对雌二醇无此作用。看来α-心钠素对卵巢类固醇生成的作用是直接的。
