Antia R, Levin B, Williamson P
Molecular and Cellular Biology Program, University of Massachusetts, Amherst.
J Theor Biol. 1991 Dec 7;153(3):371-84. doi: 10.1016/s0022-5193(05)80576-4.
A prominent and essential feature of the humoral immune response of vertebrates is immunologic memory: the ability to recall previous exposure to antigen. We present a mathematical model of the growth and interactions of the major cell populations involved in the humoral immune response. Our analysis of this model predicts that the formation of a dynamic association between small numbers of antigen-specific B and Th cells, "colocalization", is sufficient to account for memory and the kinetics of the secondary response--neither specifically differentiated Th or B memory cells nor networks of antigen and anti-idiotypes are required. The colocalization hypothesis explains a number of existing experimental observations and can be tested by straightforward experiments which we describe.
即回忆先前接触抗原的能力。我们提出了一个关于参与体液免疫反应的主要细胞群体生长和相互作用的数学模型。我们对该模型的分析预测，少量抗原特异性B细胞和Th细胞之间形成动态关联，即“共定位”，足以解释记忆和二次反应的动力学——既不需要特异性分化的Th或B记忆细胞，也不需要抗原和抗独特型网络。共定位假说解释了一些现有的实验观察结果，并且可以通过我们所描述的直接实验进行验证。
