Li Jia-Yi, Englund Elisabet, Holton Janice L, Soulet Denis, Hagell Peter, Lees Andrew J, Lashley Tammaryn, Quinn Niall P, Rehncrona Stig, Björklund Anders, Widner Håkan, Revesz Tamas, Lindvall Olle, Brundin Patrik
Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, 221 84 Lund, Sweden.
Nat Med. 2008 May;14(5):501-3. doi: 10.1038/nm1746. Epub 2008 Apr 6.
Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.
两名移植了胎儿中脑多巴胺能神经元且长期存活（11至16年）的帕金森病患者，其移植神经元中出现了α-突触核蛋白阳性的路易小体。据我们所知，我们的观察提供了首个证据，表明该疾病可从宿主细胞传播至移植细胞，这对于理解帕金森病的发病机制具有关键意义。然而，现有数据表明，十年后大多数移植细胞的功能并未受损，且接受者仍可长期缓解症状。
