Kodama Yuka, Kikusui Takefumi, Takeuchi Yukari, Mori Yuji
Laboratory of Veterinary Ethology, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-8657 Tokyo, Japan.
Dev Psychobiol. 2008 May;50(4):332-42. doi: 10.1002/dev.20289.
We investigated developmental changes in myelin formation in the prefrontal cortex and the hippocampus, and behavioral effects of early weaning in Wistar rats. Early-weaned rats showed decreased numbers of open-arm entries in an elevated plus-maze in both sexes at 4 weeks old; this effect persisted in males, but ceased in females after this age. Expression of myelin basic protein (MBP) showed both age-dependent increases and sex differences; 4-week-old males exhibited higher MBP levels in the hippocampus, whereas 7-week-old males showed lower MBP levels in the prefrontal cortex compared to females of the same age. There was a tendency for group differences from weaning for the 21.5-kDa isoform in the prefrontal cortex. Although these results suggest that male rats are more vulnerable than females to early-weaning effects on anxiety-related behaviors, further detailed analysis is needed to clarify the functional relationship between myelination and anxiety-related behaviors.
我们研究了Wistar大鼠前额叶皮质和海马体中髓鞘形成的发育变化，以及早期断奶的行为影响。早期断奶的大鼠在4周龄时，两性在高架十字迷宫中的开臂进入次数均减少；这种影响在雄性大鼠中持续存在，但在这个年龄之后，雌性大鼠不再出现。髓鞘碱性蛋白（MBP）的表达呈现出年龄依赖性增加和性别差异；4周龄雄性大鼠海马体中的MBP水平较高，而7周龄雄性大鼠前额叶皮质中的MBP水平低于同龄雌性大鼠。前额叶皮质中21.5-kDa亚型从断奶起就存在组间差异的趋势。尽管这些结果表明，雄性大鼠比雌性大鼠更容易受到早期断奶对焦虑相关行为的影响，但仍需要进一步详细分析来阐明髓鞘形成与焦虑相关行为之间的功能关系。
