Lund-Johansen P, Omvik P, White W, Digranes O, Helland B, Jordal O, Stray T
Medical Department, Section of Cardiology, Haukeland Hospital, Bergen, Norway.
Postgrad Med J. 1991;67 Suppl 5:S20-3.
Amlodipine administered once daily (5-10 mg) lowered blood pressure and reduced total peripheral resistance in patients with mild-to-severe essential hypertension without any reflex tachycardia. Heart pump function was maintained at rest and during exercise with a trend towards an increase in cardiac and stroke index. Amlodipine was effective and well tolerated in both young and elderly hypertensive patients with no reports of unpleasant vasodilator-related side effects.
氨氯地平每日服用一次（5 - 10毫克）可降低轻度至重度原发性高血压患者的血压并降低总外周阻力，且无任何反射性心动过速。在静息和运动期间，心脏泵功能得以维持，心脏指数和卒中指数有增加趋势。氨氯地平对年轻和老年高血压患者均有效且耐受性良好，未报告与血管扩张相关的不良副作用。
