氨氯地平作为一种抗缺血药物优于长效硝酸盐类药物。
Amlodipine as an antiischemic drug is superior to long acting nitrates.
作者信息
Koraćević Goran P, Dakić Sonja S, Veličković-Radovanović Radmila M, Apostolović Svetlana R, Krstić Nebojša H, Tasić Ivan S, Zdravković Marija D, Antonijević Nebojša M, Damnjanović Goran N, Kostić Tomislav L
机构信息
Department for Cardiovascular Diseases, Clinical center Niš, Bulevar Dr Z. Djindjića 48, 18000 Niš, Serbia, Medical Faculty, University of Niš, Bulevar Dr Zorana Djindjića 81, 18 000 Niš, Serbia.
Department for Cardiovascular Diseases, Clinical center Niš, Bulevar Dr Z. Djindjića 48, 18000 Niš, Serbia.
出版信息
Open Med (Wars). 2014 Nov 3;10(1):50-56. doi: 10.1515/med-2015-0011. eCollection 2015.
European Society of Cardiology Guidelines cite results of meta-analysis that the use of calcium channel blockers results in fewer angina episodes per week vs. long-acting nitrates. Moreover, we listed 12 reasons more to prefer amlodipine over long-acting nitrates, especially in stable angina pectoris patients with arterial hypertension. It may be the way to decrease polypharmacy without loosing efficacy. Some important advantages of amlodipine versus long-acting nitrate(s) are: amlodipine also treats hypertension, it helps reducing hypertensive target organ damages (e.g. left ventricular hypertrophy) and prevents morning blood pressure surge. Moreover, amlodipine can be given once daily (which improves adherence), it produces neither tolerance nor rebound, it has less side effects.
欧洲心脏病学会指南引用的荟萃分析结果表明，与长效硝酸盐相比，使用钙通道阻滞剂可使每周心绞痛发作次数减少。此外，我们还列出了12条更倾向于使用氨氯地平而非长效硝酸盐的理由，尤其是在患有动脉高血压的稳定型心绞痛患者中。这可能是一种在不降低疗效的情况下减少联合用药的方法。氨氯地平相对于长效硝酸盐的一些重要优势包括：氨氯地平还可治疗高血压，有助于减少高血压靶器官损害（如左心室肥厚）并预防晨起血压骤升。此外，氨氯地平每日服用一次（可提高依从性），不会产生耐受性或反跳现象，副作用也较少。
Zotero 插件