环磷酸腺苷依赖性蛋白激酶对海马体依赖性记忆的调节
Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase.
作者信息
Abel Ted, Nguyen Peter V
机构信息
University of Pennsylvania, Department of Biology, Biological Basis of Behavior Program, Philadelphia, PA 19104, USA.
出版信息
Prog Brain Res. 2008;169:97-115. doi: 10.1016/S0079-6123(07)00006-4.
Abstract
The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase that has been strongly implicated in the expression of specific forms of hippocampus-dependent memory. We review evidence that PKA is required for hippocampus-dependent memory in mammals, and we highlight some of the proteins that have been implicated as targets of PKA. Future directions and open questions regarding the role of PKA in memory storage are also described.
摘要
海马体对于新的陈述性长期记忆的巩固至关重要。基因和行为实验表明，几种蛋白激酶对于海马体依赖性长期记忆的形成至关重要。环磷酸腺苷依赖性蛋白激酶（PKA）是一种丝氨酸 - 苏氨酸激酶，与特定形式的海马体依赖性记忆的表达密切相关。我们综述了PKA在哺乳动物海马体依赖性记忆中发挥作用的证据，并着重介绍了一些被认为是PKA作用靶点的蛋白质。同时也描述了关于PKA在记忆存储中的作用的未来研究方向和悬而未决的问题。
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