Ma Nan, Abel Ted, Hernandez Pepe J
University of Pennsylvania, Department of Biology, Philadelphia, Pennsylvania 19104, USA.
Learn Mem. 2009 May 23;16(6):367-70. doi: 10.1101/lm.1231009. Print 2009 Jun.
It is well established that cAMP signaling within neurons plays a major role in the formation of long-term memories--signaling thought to proceed through protein kinase A (PKA). However, here we show that exchange protein activated by cAMP (Epac) is able to enhance the formation of long-term memory in the hippocampus and appears to do so independent of PKA, thus demonstrating the importance of Epac-mediated signaling in memory consolidation.
神经元内的环磷酸腺苷（cAMP）信号传导在长期记忆形成中起主要作用，这一点已得到充分证实，这种信号传导被认为是通过蛋白激酶A（PKA）进行的。然而，我们在此表明，cAMP激活的交换蛋白（Epac）能够增强海马体中长期记忆的形成，并且似乎是独立于PKA做到这一点的，从而证明了Epac介导的信号传导在记忆巩固中的重要性。
