Ackermans Linda, Temel Yasin, Visser-Vandewalle Veerle
Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands.
Neurotherapeutics. 2008 Apr;5(2):339-44. doi: 10.1016/j.nurt.2008.01.009.
Tourette's Syndrome (TS) is a neuropsychiatric disorder characterized by motor and vocal tics, often associated with behavioral disorders. Symptoms often disappear before or during adulthood. The pathophysiology of TS is still a matter of considerable debate. Current knowledge of cortico-basal ganglia-thalamocortical circuits provide explanations for the beneficial effects of deep brain stimulation (DBS) on tics. When conservative treatment fails in patients with severe TS, DBS may be a therapeutic option. In 1999, thalamic DBS was introduced for intractable TS. Since then, multiple targets have been used in a small number of patients, including the globus pallidus pars interna and the nucleus accumbens. Inclusion and exclusion criteria have been formulated to identify good candidates for DBS.
图雷特综合征(TS)是一种神经精神疾病,其特征为运动性和发声性抽动,常伴有行为障碍。症状通常在成年前或成年期间消失。TS的病理生理学仍是一个备受争议的问题。目前对皮质-基底神经节-丘脑皮质回路的认识为深部脑刺激(DBS)对抽动的有益作用提供了解释。当严重TS患者的保守治疗失败时,DBS可能是一种治疗选择。1999年,丘脑DBS被引入用于治疗难治性TS。从那时起,少数患者使用了多个靶点,包括内侧苍白球和伏隔核。已经制定了纳入和排除标准以确定DBS的合适候选者。