血清IV型胶原水平可预测重症酒精性疾病患者的食管静脉曲张。
Serum type IV collagen level is predictive for esophageal varices in patients with severe alcoholic disease.
作者信息
Mamori Satoshi, Searashi Yasuyuki, Matsushima Masato, Hashimoto Kenichi, Uetake Shinichiro, Matsudaira Hiroshi, Ito Shuji, Nakajima Hisato, Tajiri Hisao
机构信息
Division of Gastroenterology and Hepatology, Department of Internal Medicine, the Jikei University School of Medicine, Tokyo 105-8461, Japan.
出版信息
World J Gastroenterol. 2008 Apr 7;14(13):2044-8. doi: 10.3748/wjg.14.2044.
AIM
To determine factors predictive for esophageal varices in severe alcoholic disease (SAD).
METHODS
Abdominal ultrasonography (US) was performed on 444 patients suffering from alcoholism. Forty-four patients found to have splenomegaly and/ or withering of the right liver lobe were defined as those with SAD. SAD patients were examined by upper gastrointestinal (UGI) endoscopy for the presence of esophageal varices. The existence of esophageal varices was then related to clinical variables.
RESULTS
Twenty-five patients (56.8%) had esophageal varices. A univariate analysis revealed a significant difference in age and type IV collagen levels between patients with and without esophageal varices. A logistic regression analysis identified type IV collagen as the only independent variable predictive for esophageal varices (P = 0.017). The area under the curve (AUC) for type IV collagen as determined by the receiver operating characteristic (ROC) for predicting esophageal varices was 0.78.
CONCLUSION
This study suggests that the level of type IV collagen has a high diagnostic accuracy for the detection of esophageal varices in SAD.
目的
确定重度酒精性疾病（SAD）中食管静脉曲张的预测因素。
方法
对444例酒精中毒患者进行腹部超声检查（US）。44例发现有脾肿大和/或右肝叶萎缩的患者被定义为患有SAD的患者。对SAD患者进行上消化道（UGI）内镜检查以确定是否存在食管静脉曲张。然后将食管静脉曲张的存在与临床变量相关联。
结果
25例患者（56.8%）有食管静脉曲张。单因素分析显示，有和没有食管静脉曲张的患者在年龄和IV型胶原水平上存在显著差异。逻辑回归分析确定IV型胶原是食管静脉曲张的唯一独立预测变量（P = 0.017）。用于预测食管静脉曲张的IV型胶原的受试者工作特征（ROC）曲线下面积（AUC）为0.78。
结论
本研究表明，IV型胶原水平对SAD中食管静脉曲张的检测具有较高的诊断准确性。
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