McDonald Sarah D, Walker Mark C, Ohlsson Arne, Murphy Kellie E, Beyene Joseph, Perkins Sherry L
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, McMaster University, 1200 Main Street West, HSC 3N52B, Hamilton, Ontario L8N 3Z5, Canada.
Eur J Obstet Gynecol Reprod Biol. 2008 Sep;140(1):38-42. doi: 10.1016/j.ejogrb.2008.02.010. Epub 2008 Apr 18.
To determine the effect of smoking on maternal and fetal thyroid function.
This prospective cohort study involved healthy women undergoing elective cesarean section for term singleton infants. Maternal and fetal thyroid indices were compared between smokers (n=21) and non-smokers (n=83).
Maternal thyrotropin (TSH) concentrations were significantly lower in smokers than non-smokers (1.75 mIU/L versus 2.15 mIU/L, respectively, p=0.007), with similar free thyroxine (FT4) concentrations (9.59 pmol/L versus 9.56 pmol/L, p=0.755). For women who smoked, the correlation between the average number of cigarettes smoked per day and maternal TSH concentrations was -0.427, p=0.054. Infants of smokers and non-smokers had similar umbilical TSH (5.43 mIU/L versus 5.82 mIU/L, p=0.124) and FT4 concentrations (13.06 pmol/L versus 13.57 pmol/L, p=0.049).
We demonstrated for the first time that women who smoke during pregnancy have significantly lower TSH concentrations than non-smokers.
确定吸烟对母婴甲状腺功能的影响。
这项前瞻性队列研究纳入了因足月单胎婴儿而行择期剖宫产的健康女性。比较了吸烟者（n = 21）和非吸烟者（n = 83）的母婴甲状腺指标。
吸烟者的母体促甲状腺激素（TSH）浓度显著低于非吸烟者（分别为1.75 mIU/L和2.15 mIU/L，p = 0.007），游离甲状腺素（FT4）浓度相似（9.59 pmol/L和9.56 pmol/L，p = 0.755）。对于吸烟女性，每天平均吸烟支数与母体TSH浓度之间的相关性为-0.427，p = 0.054。吸烟者和非吸烟者的婴儿脐血TSH（5.43 mIU/L和5.82 mIU/L，p = 0.124）和FT4浓度（13.06 pmol/L和13.57 pmol/L，p = 0.049）相似。
我们首次证明，孕期吸烟的女性TSH浓度显著低于非吸烟者。
Zotero 插件