刺激性双结构域杀伤细胞免疫球蛋白样受体的等位基因多样性有限。
Limited allelic diversity of stimulatory two-domain killer cell immunoglobulin-like receptors.
作者信息
Hou Lihua, Steiner Noriko K, Chen Minghua, Belle Ian, Kubit Anna L, Ng Jennifer, Hurley Carolyn Katovich
机构信息
Department of Pediatrics, CW Bill Young Marrow Donor Recruitment and Research Program, Georgetown University Medical Center, Washington, DC, USA.
出版信息
Hum Immunol. 2008 Mar;69(3):174-8. doi: 10.1016/j.humimm.2008.01.009. Epub 2008 Feb 25.
Genomic sequencing was used to characterize most of the coding regions of the five two-domain stimulatory killer cell immunoglobulin-like receptor (KIR) loci from 80 unrelated, primarily Caucasian, individuals. Specific loci were present in from 26% (KIR2DS3) to 98% (KIR2DS4) of individuals. The number of known alleles present varied from one (KIR2DS1, KIR2DS5) to five (KIR2DS4). The frequencies of loci and alleles were similar to observations made in populations of European and Asian ethnicities. New alleles were found at 2DS1 (*00202, *00302, *005, *006, *007) and 2DS4 (*008) loci.
采用基因组测序对来自80名无亲缘关系、主要为白种人的个体的五个双结构域刺激性杀伤细胞免疫球蛋白样受体（KIR）基因座的大部分编码区进行了特征分析。特定基因座在26%（KIR2DS3）至98%（KIR2DS4）的个体中存在。已知等位基因的数量从一个（KIR2DS1、KIR2DS5）到五个（KIR2DS4）不等。基因座和等位基因的频率与欧洲和亚洲种族人群中的观察结果相似。在2DS1（*00202、*00302、*005、*006、*007）和2DS4（*008）基因座发现了新的等位基因。
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