稳定型和不稳定型哮喘患者呼出气冷凝物中的内皮素-1

Endothelin-1 in exhaled breath condensate of stable and unstable asthma patients.

作者信息

Zietkowski Z, Skiepko R, Tomasiak M M, Bodzenta-Lukaszyk A

机构信息

Department of Allergology and Internal Medicine, Medical University of Bialystok, Poland.

出版信息

Respir Med. 2008 Mar;102(3):470-4. doi: 10.1016/j.rmed.2007.10.013.

DOI:10.1016/j.rmed.2007.10.013

PMID:18396516

Abstract

Endothelins are proinflammatory, profibrotic, broncho- and vasoconstrictive peptides, which play an important role in the development of airway inflammation and remodeling in asthma. The study was undertaken to evaluate the endothelin-1 (ET-1) levels in exhaled breath condensate (EBC) of asthmatics with different degree in asthma severity. EBC was collected from 31 patients with allergic asthma (11 with steroid-naïve mild asthma, 10 with ICS-treated, stable mild-to-moderate asthma, 10 with ICS-treated unstable, severe asthma) and 7 healthy volunteers. In the three groups of asthmatics, ET-1 concentrations in EBC were significantly higher than in healthy volunteers. ET-1 levels were significantly higher in patients with unstable asthma than in the two groups with stable disease. There was a significant correlation between ET-1 levels and FENO in the three groups of asthmatics and between ET-1 and blood eosinophil counts in the group of patients with unstable asthma. Measurements of ET-1 in EBC may provide another useful diagnostic tool for detecting and monitoring inflammation in patients with asthma.

摘要

内皮素是促炎、促纤维化、支气管和血管收缩肽，在哮喘气道炎症和重塑的发展中起重要作用。本研究旨在评估不同哮喘严重程度的哮喘患者呼出气冷凝液（EBC）中的内皮素-1（ET-1）水平。收集了31例过敏性哮喘患者（11例初治轻度哮喘患者、10例接受吸入性糖皮质激素（ICS）治疗的稳定轻度至中度哮喘患者、10例接受ICS治疗的不稳定重度哮喘患者）和7名健康志愿者的EBC。在三组哮喘患者中，EBC中的ET-1浓度显著高于健康志愿者。不稳定哮喘患者的ET-1水平显著高于两组稳定疾病患者。三组哮喘患者中ET-1水平与呼出一氧化氮（FENO）之间以及不稳定哮喘患者组中ET-1与血液嗜酸性粒细胞计数之间存在显著相关性。检测EBC中的ET-1可能为检测和监测哮喘患者的炎症提供另一种有用的诊断工具。