Sahu A P, Shanker R, Dogra R K, Zaidi S H
Exp Pathol (Jena). 1975;10(1-2):83-5. doi: 10.1016/s0014-4908(75)80008-1.
Intratracheal inoculations of quartz dust (250 mg/kg body weight) of a particle size less than 5 mum were given in mice and pulmonary tissue reactions studied over a period of 210 days. Acute inflammatory reaction in the lung parenchyma was observed at early periods and later the aggregates of dust laden macrophages encountered around bronchi and blood vessels. Towards the termination of the experiment at 210 days the fibrotic reaction comprised chiefly of thick compactly arranged reticulin fibers with few collagen fibers which remained restricted to the peribronchial and perivascular areas. There was no silicotic nodule formation in the parenchyma of the lung. The atypical pulmonary tissue response to quartz dust in mice has been attributed to different tissue reactivity.
给小鼠气管内接种粒径小于5微米的石英粉尘（250毫克/千克体重），并在210天的时间内研究肺组织反应。在早期观察到肺实质有急性炎症反应，后期在支气管和血管周围发现了充满粉尘的巨噬细胞聚集体。在实验第210天结束时，纤维化反应主要由紧密排列的粗大网状纤维组成，只有少量胶原纤维，且局限于支气管周围和血管周围区域。肺实质中未形成硅结节。小鼠对石英粉尘的非典型肺组织反应归因于不同的组织反应性。
