Mehrotra N K, Chandra H, Gupta G S
Exp Pathol (Jena). 1975;10(1-2):66-71. doi: 10.1016/s0014-4908(75)80006-8.
The cirrhosis in male albino rats was produced after repeated subcutaneous injections of carbon tetrachloride, in dosage schedule as described. A fully developed cirrhosis was observed after 150 days. The silicosis in lungs was produced after single intratracheal injection of silica dust of particle size less than 5 microns and studied up to 180 days. The effect of damaged liver on the development of silicosis in the lungs was studied. It was found that pulmonary fibrosis caused by silica dust appeared to be a tissue reaction confined to the lung tissue alone. The dysfunction of liver did not exert any influence on fibrogenesis in the lungs.
雄性白化大鼠的肝硬化是通过按照所述剂量方案反复皮下注射四氯化碳产生的。150天后观察到完全发展的肝硬化。肺部硅沉着病是通过单次气管内注射粒径小于5微米的二氧化硅粉尘产生的，并进行了长达180天的研究。研究了受损肝脏对肺部硅沉着病发展的影响。发现由二氧化硅粉尘引起的肺纤维化似乎是仅局限于肺组织的组织反应。肝脏功能障碍对肺部纤维生成没有任何影响。
