Diawara Silman, Toure Kane Coumba, Legoff Jérôme, Gaye Astou Gueye, Mboup Souleymane, Bélec Laurent
Hôpital Militaire de Ouakam, Dakar, Sénégal.
Int J STD AIDS. 2008 Mar;19(3):159-60. doi: 10.1258/ijsa.2007.007139.
Herpes simplex virus type 2 (HSV-2) is considered as a major co-factor of both sexual transmission and acquisition of the human immunodeficiency virus (HIV). The HIV epidemic in Senegal is characterized by a remarkable and stable low prevalence. Whether HSV-2 may also constitute a possible co-factor favouring the spreading of HIV epidemic in Senegal is yet unknown. This prompted us to evaluate the HSV-2 seroprevalence in the sentinel population of pregnant women in Senegal. Two hundred and sixty pregnant women attending Roi Baudouin maternity in the capital city Dakar (n = 14; 135) and the antenatal clinic in Kaolack (n = 125), the third city of Senegal, were prospectively recruited between March and August 2003. Fifty-six women (22%) were positive for HSV-2 serology. The prevalence of HSV-2 seropositivity was higher in women living in Dakar (26%) than in those living in Kaolack (16%) (P < 0.01). Only two women from Dakar and two other from Kaolack were found to be HIV-1-infected. Our observations suggest a seemingly low seroprevalence of HSV-2 infection in adult women Senegal, comparable with those usually reported in Western countries. Further, epidemiological surveys are needed to confirm these results in the general population.
2型单纯疱疹病毒（HSV-2）被认为是人类免疫缺陷病毒（HIV）性传播和感染的主要协同因素。塞内加尔的HIV疫情特点是感染率显著且稳定地保持在低水平。HSV-2是否也可能是促使HIV在塞内加尔传播的一个协同因素，目前尚不清楚。这促使我们对塞内加尔孕妇哨点人群中的HSV-2血清流行率进行评估。2003年3月至8月期间，前瞻性招募了260名在首都达喀尔的罗伊·鲍杜因妇产医院就诊的孕妇（n = 145）以及在塞内加尔第三大城市考拉克的产前诊所就诊的孕妇（n = 115）。56名女性（22%）的HSV-2血清学检测呈阳性。居住在达喀尔的女性中HSV-2血清阳性率（26%）高于居住在考拉克的女性（16%）（P < 0.01）。仅发现来自达喀尔的两名女性和来自考拉克的另外两名女性感染了HIV-1。我们的观察结果表明，塞内加尔成年女性中HSV-2感染的血清流行率似乎较低，与西方国家通常报告的情况相当。此外，需要进行进一步的流行病学调查以在普通人群中证实这些结果。
