产前缺氧对中枢神经系统心电图参数的年龄特异性动态变化及生物胺含量的影响。

Effect of antenatal hypoxia on age-specific dynamics of ECG parameters and content of biogenic amines in the central nervous system.

作者信息

Graf A V, Maslova M V, Trofimova L K, Dunaeva T Yu, Sokolova N A, Kudryashova N Yu, Krushinskaya Ya V, Goncharenko E N

机构信息

Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University.

出版信息

Bull Exp Biol Med. 2007 Aug;144(2):188-91. doi: 10.1007/s10517-007-0286-5.

DOI:10.1007/s10517-007-0286-5

PMID:18399277

Abstract

We studied the effect of acute antenatal hypoxia during the stages of progestation and early organogenesis on some ECG parameters and level of biogenic amines in brain structures in rats. The effect of acute hypoxic exposure during the organogenesis period on the studied parameters was more pronounced than the effect of acute hypoxic exposure during the progestation period. The shift of the autonomic balance towards the sympathetic regulation of cardiac activity is linked with increased content of biogenic amines in the brain stem and cortical structures.

摘要

我们研究了妊娠前期和早期器官形成阶段急性产前缺氧对大鼠某些心电图参数和脑结构中生物胺水平的影响。器官形成期急性缺氧暴露对所研究参数的影响比妊娠前期急性缺氧暴露的影响更为显著。自主平衡向心脏活动的交感神经调节方向转变与脑干和皮质结构中生物胺含量增加有关。