IEM - 1966与美金刚对实验性变态反应性脑脊髓炎大鼠预防和治疗作用的比较研究

Comparative study of preventive and therapeutic effects of IEM-1966 and memantine in rats with experimental allergic encephalomyelitis.

作者信息

Abdurasulova I N, Serdyuk S E, Gmiro V E

机构信息

S. V. Anichkov Department of Neuropharmacology, I. P. Pavlov Department of Physiology, State Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.

出版信息

Bull Exp Biol Med. 2007 Aug;144(2):217-20. doi: 10.1007/s10517-007-0293-6.

DOI:10.1007/s10517-007-0293-6

PMID:18399284

Abstract

We compared preventive and therapeutic effects of memantine, a selective blocker of NMDA-receptors, and IEM-1966, a blocker of both NMDA- and GluR1 AMPA-receptors, on the model of acute experimental allergic encephalomyelitis. Memantine in high doses prevented the development of experimental allergic encephalomyelitis only in 10% rats, slightly (by 1.4-1.5 times) moderated the neurological disturbances, and shortened the duration of the disease. In far lower doses, IEM-1966 prevented the development of experimental allergic encephalomyelitis in 50% rats, while in the affected rats it decreased the severity of neurological disturbances and duration of the disease by 3-4 times. When applied during the clinical phase of the disease, IEM-1966 decreased the severity of neurological disturbances and duration of the disease by 2.0-2.5 times predominantly in rats with mild and moderate course of experimental allergic encephalomyelitis.

摘要

我们比较了美金刚（一种N-甲基-D-天冬氨酸（NMDA）受体选择性阻滞剂）和IEM-1966（一种NMDA和α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体阻滞剂）对急性实验性过敏性脑脊髓炎模型的预防和治疗作用。高剂量美金刚仅在10%的大鼠中预防了实验性过敏性脑脊髓炎的发生，轻微（1.4至1.5倍）减轻了神经功能障碍，并缩短了疾病持续时间。IEM-1966以低得多的剂量在50%的大鼠中预防了实验性过敏性脑脊髓炎的发生，而在患病大鼠中，它将神经功能障碍的严重程度和疾病持续时间降低了3至4倍。在疾病临床阶段应用时，IEM-1966主要在实验性过敏性脑脊髓炎轻度和中度病程的大鼠中，将神经功能障碍的严重程度和疾病持续时间降低了2.0至2.5倍。